Projects

Project Area A

Projects belonging to Area A are focusing on steady state scenarios. Within these projects we aim at understanding the niche-specific factors that determine Treg cell phenotypes and functions.

Project A01

Dynamics, epigenetic signatures and modulating factors of tissue Treg cell differentiation

Project A02

Role and regulation of muscle-residing Foxp3⁺ Treg cells in health and disease

Project A04

The role of cAMP in regulatory T cell homeostasis and function

Project A05

Regulation of Treg cell subsets and function by the atypical IκB protein Bcl-3

Project A06

Post-transcriptional control of tissue-resident regulatory T cells

Project A07

Investigating Treg cell plasticity in mice and man

Project A08

The role of non-canonical NF-κB signaling in Treg cells in tissue homeostasis and disease

Project A09

CK2 as a molecular switch regulating immunity and tolerance by APC-dependent induction of Treg cells

Project A10

Myeloid cell-regulatory T cell crosstalk in thrombus development and resolution

Area B projects address conditions deviating from the steady state situation. We focus on how diseases affecting the central nervous system, the intestine, or the pancreas alter the Treg cell signatures, allowing us to identify novel strategies for Treg cell-based therapies.