Regulatory T cells (Treg cells) are considered crucial modifiers of immune responses. It is becoming increasingly evident that Treg cells are a far more heterogenous cell population than previously appreciated. However, the cellular interaction partners of Treg cells in distinct niche-specific contexts as well as the code(s) that tissue-resident Treg cells use to communicate with other cell types are largely unknown. Moreover, it is unclear how Treg cell heterogeneity develops and how it is maintained.
We believe that it's time to re-think Treg cell biology for the development of tailored immune therapies that also target organ regeneration and restore tissue homeostasis
Our team of researchers pursues a concerted effort that aims to identify organ-specific and disease-specific molecules or processes that might qualify for further validation as targets for interventional approaches.
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12.08.2025
Polyamines regulate adaptive antitumor immunity by functional specialization of regulatory T cells
Georg Bündgen, Alexander Ulges, Jan Pietruschka, Natalia Truong-Andrievici, Matthias Klein, Karolina Romaniuk, Fabian Schmitt, Mathias Hagen, Joachim G. Seebass, Lenart Zezlina, Lara Stein, Hans Christian Probst, Ute Distler, Stefan Tenzer, Michael Lohoff, Addi J. Romero-Olmedo, Henrik Mei, Toszka Bohn, Michael Delacher, Thierry Schmidlin, Matthias M. Gaida, Ivan Dikic, Charles Imbusch, Hansjörg Schild, Tobias Bopp
16.07.2025
Niklas Beumer, Charles D. Imbusch, Tamara Kaufmann, Lisa Schmidleithner, Kathrin Gütter, Philipp Stüve, Harriet Marchel, Dieter Weichenhan, Marion Bähr, Brigitte Ruhland, Federico Marini, Lieke Sanderink, Uwe Ritter, Malte Simon, Kathrin Luise Braband, Morten Michael Voss,