Transregional Collaborative Research Centre

Regulatory T cells (Treg cells) are considered crucial modifiers of immune responses. It is becoming increasingly evident that Treg cells are a far more heterogenous cell population than previously appreciated. However, the cellular interaction partners of Treg cells in distinct niche-specific contexts as well as the code(s) that tissue-resident Treg cells use to communicate with other cell types are largely unknown. Moreover, it is unclear how Treg cell heterogeneity develops and how it is maintained.