Regulatory T cells (Treg cells) are considered crucial modifiers of immune responses. It is becoming increasingly evident that Treg cells are a far more heterogenous cell population than previously appreciated. However, the cellular interaction partners of Treg cells in distinct niche-specific contexts as well as the code(s) that tissue-resident Treg cells use to communicate with other cell types are largely unknown. Moreover, it is unclear how Treg cell heterogeneity develops and how it is maintained.
We believe that it's time to re-think Treg cell biology for the development of tailored immune therapies that also target organ regeneration and restore tissue homeostasis
Our team of researchers pursues a concerted effort that aims to identify organ-specific and disease-specific molecules or processes that might qualify for further validation as targets for interventional approaches.
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29.09.2026
Gut microbiota primes stroke severity via the AHR in intestinal dendritic cells
Rosa Delgado Jiménez, Alexandria Ruggles, Mujeeb Adekunle Adedokun, Adam Sorbie, Diana Fink, Samuele Laudani, Alba Simats, Yufei He, Vanessa Pahl, Laura Díaz-Marugán, Morten Voss, Kartikeya Singh, Miquel Lledós, Olga Carofiglio, Philip Melton, Kelsey Pinkham, Alessio Ricci, Stefan Roth, Rebecca Sadler, Svetlina Khayat, Seyedeh Maryam Mousavi, Thanos Tsaktanis, Ann-Marie Tobinski, Carolin Walter, Caspar Ohnmacht, Jochen Huehn, Johannes Herkel, Antonella Carambia, Luisa Klotz, Mathias Gelderblom, Veit Rothhammer, Tommy Regen, Jürgen Bernhagen, Michael Gigl, Michael Zimmermann, Israel Fernandez-Cadenas, Lorenz Hirt, Michael Delacher, Arthur Liesz, Corinne Benakis
16.09.2026